Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

• Richard J. Ingham,
• Claudio Battilocchio,
• Joel M. Hawkins and
• Steven V. Ley

Beilstein J. Org. Chem. 2014, 10, 641–652, doi:10.3762/bjoc.10.56

• explored the possibility of developing a machine-automated synthesis of this compound which might later be extended to analogous structures. For the facile machine-assisted synthesis of 1 we devised and optimised the fully continuous sequential hydration of nitrile 3 to amide 2 and hydrogenation of

• increasing availability of free and open software to enable such processes will help to democratise the field of flow chemistry when applied as an advanced enabling technology in the laboratory. Conclusion A machine assisted synthesis of pyrazine-2-carboxamide – a component of Rifater®, used in the treatment

• (shown highlighted with a box) and report its height from the bottom of the image. Flow set up for the automated machine assisted synthesis of (R,S)-piperidine-2-carboxamide. Control sequence for the two-step process. Chart of monitored parameters over a 15 hour reaction. The output from the hydrolysis

Camera-enabled techniques for organic synthesis

• Steven V. Ley,
• Richard J. Ingham,
• Matthew O’Brien and
• Duncan L. Browne

Beilstein J. Org. Chem. 2013, 9, 1051–1072, doi:10.3762/bjoc.9.118

• of the future. Keywords: automation; computer vision; digital camera; flow chemistry; machine-assisted synthesis; Introduction The increasing prevalence of digital camera technology for capturing images, videos and visible information is having a profound impact on many aspects of our modern